8 teams qualify (5 aggregate winners, the remaining berths will go in order to 2003 league champion Charleston, 2003 league runners-up Minnesota and the club with the highest point percentage through matches on May 23, which will also be used for the other two berths should Charleston and Minnesota win their respective series.)

April 30 Richmond Kickers 1 - 1(aet) Virginia Beach Mariners

(Rich - Joey Worthen 69'  VB - Jakob Fenger 43')

May 1   Richmond Kickers 2 - 0 Virginia Beach Mariners

(Rich - Kevin Jeffery 12', Matthew Delicate 28')

Richmond qualify for US Open Cup on 3-1 aggreggate

May 1   Portland Timbers 2 - 1 Seattle Sounders
(Por - Alan Gordon 1', Byron Alvarez 71'  Sea - Kyle Smith 75')

May 15 Portland Timbers 1 - 0 Seattle Sounders
(Por - Jake Sagare 52')

Portland qualify for US Open Cup on 3-1 Aggreggate

May 8  Atlanta Silverbacks  2 - 0 Charleston Battery
(Atl - John Ball 67', Velko Iotov 85')

May 15 Atlanta Silverbacks  2 - 2(aet) Charleston Battery
(Atl - Mac Cozier 43', 77'; Char - Ted Chronopoulos 51', Greg Simmonds 69')

Atlanta qualify for US Open Cup on 4-2 aggreggate

May 21 Minnesota Thunder   1 - 0(aet) Milwaukee Wave United
(Min - Christopher Vorenkamp 110')

May 22 Minnesota Thunder  0 - 0(aet) Milwaukee Wave United

Minnesota qualify for US Open Cup on 1-0 aggreggate

May 14 Syracuse Salty Dogs 1 - 1(aet) Rochester Rhinos
(Syr - Christian Neagu 6'; Roc - Corey Woolfolk 67')

May 22 Syracuse Salty Dogs 0 - 1 Rochester Rhinos
(Roc - Doug Miller 84')

Rochester qualify for US Open Cup on 2-1 aggreggate