The Michigan Bucks, who are returning the majority of their championship roster from last year, got their season off on the right foot with a 4-0 win at West Michigan on Wednesday. Khelli Dube scored twice and last year’s PDL assist leader Nate Jafta scored a goal and added an assist. With a "maximum points win" (winning a game by three or more goals and scoring three or more goals), the Bucks held onto first place in the Central Conference, that was until the Indiana Invaders score came in.

After opening their season with a road win on Monday at Fort Wayne, the Invaders were held to a 1-1 draw against the Chicago Fire Premier at Toyota Park. Indiana would have claimed all three points, but Northern Illinois striker Marcus McCarty scored the equalizer for the Fire Premier in the 90th minute.

The third game in the Central Conference was the home opener for the Kansas City Brass, as they upset the Des Moines Menace 3-1. Both teams traded goals midway through the first half, but it was the home side that scored just before halftime to make it 2-1. A 75th minute goal by the Brass would put the game out of reach, and give the Brass the victory. Kansas City has not qualified for the Open Cup since 1998, when they took a professional team (Central Jersey Riptide - D3) to extra time before falling 2-1.

There were two games in the Eastern Conference on Wednesday. The Cape Cod Crusaders have picked up right where they left off last year, improving to 2-0-0 with a 4-0 win over the Rhode Island Stingrays. Last year, Cape Cod finished unbeaten (14-0-2) before losing in the conference finals. And finally, the Virginia Legacy’s hopes of finishing unbeaten in qualifying were stopped by the Reading Rage, 2-1.